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Journal of Biological Rhythms

Journal of Biological Rhythms - https://drive.google.com/file/d/1wxVyBHz5j8PorKqsxZFRkiv54hZtqtIe/view?usp=drive_link

<strong>Abstract</strong>

Circadian rhythms represent an adaptive feature, ubiquitously found in nature, which grants living beings the ability to anticipate daily variations in their environment. They have been found in a multitude of organisms, ranging from bacteria to fungi, plants, and animals. Circadian rhythms are generated by endogenous clocks that can be entrained daily by environmental cycles such as light and temperature. The molecular machinery of circadian clocks includes a transcriptional-translational feedback loop that takes approximately 24 h to complete. Drosophila melanogaster has been a model organism of choice to under stand the molecular basis of circadian clocks. However, alternative animal mod els are also being adopted, each offering their respective experimental advantages. The nematode Caenorhabditis elegans provides an excellent model for genetics and neuro-behavioral studies, which thanks to its ease of use and manipulation, as well as availability of genetic data and mutant strains, is currently used as a novel model for circadian research. Here, we aim to evaluate C. elegans as a model for chronobiological studies, focusing on its strengths and weaknesses while reviewing the available literature. Possible zeitgebers (including light and temperature) are also discussed. Determining the molecular bases and the neu ral circuitry involved in the central pacemaker of the C. elegans’ clock will con tribute to the understanding of its circadian system, becoming a novel model organism for the study of diseases due to alterations of the circadian cycle.

Buscador UdeSA

Caenorhabditis elegans as a Promising Model Organism in Chronobiology

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UdeSA - Universidad de San Andrés

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