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Proceedings of the National Academy of Sciences

Proceedings of the National Academy of Sciences - https://drive.google.com/file/d/1EUopWu9efw2ys0DuTihArC-yOocrczOK/view?usp=drive_link

We show that nocturnal aversive stimuli presented to mice while they are eating and drinking outside of their safe nest can entrain circadian behaviors, leading to a shift toward daytime activity. We also show that the canonical molecular circadian clock is necessary for fear entrainment and that an intact molecular clockwork in the supra chiasmatic nucleus, the site of the central circadian pacemaker, is necessary but not sufficient to sustain fear entrainment of circadian rhythms. Our results demonstrate that entrainment of a circadian clock by cyclic fearful stimuli can lead to severely mistimed circadian behavior that persists even after the aversive stimulus is removed. Together, our findings support the interpretation that circadian and sleep symptoms associated with fear and anxiety disorders are, in part, the output of a fear- entrained clock, and provide a mechanistic insight into this clock.

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The circadian molecular clock in the suprachiasmatic nucleus is necessary but not sufficient for fear entrainment

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