622.png

Multivariate word properties in fluency tasks 

Multivariate word properties in fluency tasks  - https://europepmc.org/article/MED/37823470

Introduction: Verbal fluency tasks are common in Alzheimer’s disease (AD) assessments. Yet, standard valid response counts fail to reveal disease-specific semantic memory patterns. Here we leveraged automated word-property analysis to capture neurocognitive markers of AD vis-à-vis behavioral variant frontotemporal dementia (bvFTD). METHODS: Patients and healthy controls completed two fluency tasks. We counted valid responses and computed each word’s frequency, granularity, neighborhood, length, familiarity, and imageability. These features were used for group-level discrimination, patient-level identification, and correlations with executive and neural (MRI, fMRI, EEG) patterns.

Results: Valid responses revealed deficits in both disorders. Conversely, frequency, granularity, and neighborhood yielded robust group- and subject-level discrimination only in AD, also predicting executive outcomes. Disease-specific cortical thickness patterns were predicted by frequency in both disorders. Default-mode and salience network hypoconnectivity, and EEG beta hypoconnectivity, were predicted by frequency and granularity only in AD.

Discussion: Word-property analysis of fluency can boost AD characterization and diagnosis.

Buscador UdeSA

Multivariate word properties in fluency tasks reveal markers of Alzheimer’s dementia

Acceso al Paper

Nuestras sedes:

UdeSA - Universidad de San Andrés

Comunidad Ampliada San Andrés: