Physical Review E

<article class="align-center media media--type-link media--view-mode-default"><div class="field field--name-field-media-entity-link field--type-link field--label-hidden field__item"><a href="https://doi.org/10.1103/PhysRevE.82.031910" target="_blank">82, pp. 31910-31921</a></div>
 
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Stochastic fire-diffuse-fire model with realistic cluster dynamics

Stochastic fire-diffuse-fire model with realistic cluster dynamics - https://doi.org/10.1103/PhysRevE.82.031910

Abstract

Living organisms use waves that propagate through excitable media to transport information. Ca2+ waves are a paradigmatic example of this type of processes. A large hierarchy of Ca2+ signals that range from localized release events to global waves has been observed in Xenopus laevis oocytes. In these cells, Ca2+ release occurs trough inositol 1,4,5-trisphosphate receptors (IP3Rs) which are organized in clusters of channels located on the membrane of the endoplasmic reticulum. In this article we construct a stochastic model for a cluster of IP3R’s that replicates the experimental observations reported in [D. Fraiman et al., <a href="http://dx.doi.org/10.1529/biophysj.105.075911">Biophys. J. 90, 3897 (2006)</a>]. We then couple this phenomenological cluster model with a reaction-diffusion equation, so as to have a discrete stochastic model for calcium dynamics. The model we propose describes the transition regimes between isolated release and steadily propagating waves as the IP3 concentration is increased.

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Stochastic fire-diffuse-fire model with realistic cluster dynamics

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